Cdh4^{tm1(cre/ERT2)Jrs}
Targeted Allele Detail

Summary

• Symbol: Cdh4^{tm1(cre/ERT2)Jrs}
• Name: cadherin 4; targeted mutation 1, Joshua R Sanes
• MGI ID: MGI:5896331
• Synonyms: Cdh4^CreER
• Gene: Cdh4 Location: Chr2:179084228-179541166 bp, + strand Genetic Position: Chr2, 101.86 cM
• Alliance: Cdh4^{tm1(cre/ERT2)Jrs} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235958
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Cdh4^{tm1(cre/ERT2)Jrs} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cdh4 (MGI:99218)

• Mutation details: The targeting vector consisting of a FRT flanked neo cassette, a 6xmyc-tagged CreER-T2, and poly-adenylation signal replaced N-term 19 amino acid at the translational start site of the mouse Cdh4 via homologous recombination. (J:235958)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cdh4 (mouse) Summary of all recombinase alleles driven by Cdh4. Alliance mouse Cdh4 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh4 Mutation: 56 strains or lines available

References

• Original: J:235958 Rousso DL, et al., Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016 May 31;15(9):1930-44
• All: 2 reference(s)