Tg(CAG-Ppard*E411P)#Als
Transgene Detail

Summary

• Symbol: Tg(CAG-Ppard*E411P)#Als
• Name: transgene insertion, Albert R La Spada
• MGI ID: MGI:5897172
• Synonyms: Ppard^E411P
• Transgene: Tg(CAG-Ppard*E411P)#Als Location: unknown
• Alliance: Tg(CAG-Ppard*E411P)#Als page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Ppard*E411P)#Als expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ppard (MGI:101884)

• Mutation details: This transgene consists of a combined beta-actin promoter-cytomegalovirus enhancer, a STOP cassette flanked by loxP sites and the mouse Ppard cDNA with a single amino acid mutation, a substitution of proline for glutamate at residue 411 (E411P). Cre-mediated recombination can be used to remove the STOP cassette and express the mutant protein. This mutation inhibits Ppard transactivation in a dominant-negative manner. (J:233176)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:233176 Dickey AS, et al., PPAR-delta is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nat Med. 2016 Jan;22(1):37-45
• All: 1 reference(s)