Opn5^tm1.1Lan
Targeted Allele Detail

Summary

• Symbol: Opn5^tm1.1Lan
• Name: opsin 5; targeted mutation 1.1, Richard A Lang
• MGI ID: MGI:5897189
• Gene: Opn5 Location: Chr17:42867674-42922286 bp, - strand Genetic Position: Chr17, 19.65 cM, cytoband B3
• Alliance: Opn5^tm1.1Lan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227078
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Using PCS6008_A_B12 from KOMP containing an FRT-lacZ cassette and loxP-flanked neomycin under the control of the human beta-actin promoter, SV40 poly A, a second FRT site and a second loxP site were inserted before exon 4. A third loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exon 4. (J:227078)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Opn5 Mutation: 19 strains or lines available

References

• Original: J:227078 Buhr ED, et al., Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13093-8
• All: 1 reference(s)