Opn3tm2b(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Opn3tm2b(EUCOMM)Wtsi |
Name: |
opsin 3; targeted mutation 2b, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5897190 |
Synonyms: |
Opn3lacz |
Gene: |
Opn3 Location: Chr1:175489993-175520198 bp, - strand Genetic Position: Chr1, 81.66 cM, cytoband H3
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Alliance: |
Opn3tm2b(EUCOMM)Wtsi page
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IMPC: |
Opn3 gene page |
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Mutant Cell Line: |
EPD0197_3_E01 |
Germline Transmission: |
Earliest citation of germline transmission:
J:227078
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 175492614 of Chromosome 1 upstream of the critical exon 2 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 2 at position 175493673. The critical exon 2 is thus flanked by loxP sites. Cre expression occur without flp expression generates a reporter knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml.
(J:227078)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Opn3 Mutation: |
25 strains or lines available
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Original: |
J:227078 Buhr ED, et al., Neuropsin (OPN5)-mediated photoentrainment of local circadian oscillators in mammalian retina and cornea. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):13093-8 |
All: |
5 reference(s) |
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