Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
• Name: transgene insertion 1, Jeffery Molkentin
• MGI ID: MGI:5897311
• Transgene: Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol Location: unknown
• Alliance: Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Tnnc1 (290561)

  Tnnc1

  (MGI:98779)

  contains I61Q substitution

• Mutation details: Mice bearing this transgene conditionally express FLAG-tagged rat Tnnc1 (troponin C, cardiac/slow skeletal) cDNA carrying an I61Q (ATC->CAG) mutation under the control of the mouse cardiac-specific Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter and the tetracycline responsive element (tetO). The transgene elicits ~45% incorporation of the mutant cardiac troponin C into the cardiac muscle sarcomere. (J:234490)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice exhibit 5% to 10% replacement at baseline in the absence of tTA transgene.

References

• Original: J:234490 Davis J, et al., A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy. Cell. 2016 May 19;165(5):1147-59
• All: 2 reference(s)