Tg(Myh6-Atp1a2)1Jmol
Transgene Detail

Summary

• Symbol: Tg(Myh6-Atp1a2)1Jmol
• Name: transgene insertion 1, Jeffery Molkentin
• MGI ID: MGI:5897332
• Transgene: Tg(Myh6-Atp1a2)1Jmol Location: unknown
• Alliance: Tg(Myh6-Atp1a2)1Jmol page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Atp1a2)1Jmol expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Atp1a2 (24212)

  Atp1a2

  (MGI:88106)

• Mutation details: Mice bearing this transgene express rat Atp1a2 (ATPase, Na+/K+ transporting, alpha 2 polypeptide; also called NKA-alpha2) cDNA under the control of the mouse heart-specific Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter. (J:223625)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:223625 Correll RN, et al., Overexpression of the Na+/K+ ATPase alpha2 but not alpha1 isoform attenuates pathological cardiac hypertrophy and remodeling. Circ Res. 2014 Jan 17;114(2):249-56
• All: 2 reference(s)