Wnt11^tm1.1Sev
Targeted Allele Detail

Summary

• Symbol: Wnt11^tm1.1Sev
• Name: wingless-type MMTV integration site family, member 11; targeted mutation 1.1, Sylvia Evans
• MGI ID: MGI:5897623
• Synonyms: Wnt11^flox
• Gene: Wnt11 Location: Chr7:98484293-98503954 bp, + strand Genetic Position: Chr7, 53.9 cM
• Alliance: Wnt11^tm1.1Sev page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248849
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a second loxP site followed by an FRT-flanked MLC-neo cassette is inserted downstream of exon 4. The selection cassette was deleted by FLP recombinase. (J:248849)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wnt11 Mutation: 22 strains or lines available

References

• Original: J:248849 van Vliet PP, et al., Tissue specific requirements for WNT11 in developing outflow tract and dorsal mesenchymal protrusion. Dev Biol. 2017 Sep 1;429(1):249-259
• All: 1 reference(s)