Tg(RP11-H2112)9Trme
Transgene Detail

Summary

• Symbol: Tg(RP11-H2112)9Trme
• Name: transgene insertion 9, Trevelyan R Menheniott
• MGI ID: MGI:5898086
• Transgene: Tg(RP11-H2112)9Trme Location: unknown
• Alliance: Tg(RP11-H2112)9Trme page

Transgene origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(RP11-H2112)9Trme expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GKN1 (56287)

  Gkn1	(MGI:1913533)

  human

  GKN2 (200504)

  Gkn2	(MGI:1913534)

• Mutation details: A 152 kb BAC fragment containing the human GKN1 and GKN2 genomic region was used to create this transgene. Two lines, 5 and 9, were created. Expression of the transgene is restricted to only gastric surface mucus cells. (J:234656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:234656 Menheniott TR, et al., Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression. J Clin Invest. 2016 Apr 1;126(4):1383-400
• All: 1 reference(s)