Mstn^tm3.1Sjl
Targeted Allele Detail

Summary

• Symbol: Mstn^tm3.1Sjl
• Name: myostatin; targeted mutation 3.1, Se-Jin Lee
• MGI ID: MGI:5898564
• Synonyms: flox
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^tm3.1Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240862
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP-flanked neomycin selection cassette was inserted downstream of exon 3, and subsequent breeding to a Cre-deleter excised the neomycin selection cassette yielding this conditional ready allele. (J:240862)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 34 strains or lines available

References

• Original: J:240862 Lee YS, et al., Paracrine and endocrine modes of myostatin action. J Appl Physiol (1985). 2016 Mar 15;120(6):592-8
• All: 1 reference(s)