Tg(Lck-cre)7Syt
Transgene Detail

Summary

• Symbol: Tg(Lck-cre)7Syt
• Name: transgene insertion 7, Huey-Kang Sytwu
• MGI ID: MGI:5901742
• Synonyms: Tg(Lck-cre)7Sytwu
• Transgene: Tg(Lck-cre)7Syt Location: unknown
• Alliance: Tg(Lck-cre)7Syt page

Transgene origin

• Strain of Origin: NOD/ShiLtJSyt

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lck-cre)7Syt expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Lck

• Mutation details: A transgene construct containing proximal lymphocyte protein tyrosine kinase (Lck) promoter driving cre recombinase was used to create transgenic line in NOT/Sytwu mouse. At least two lines 7 and 14 were made. Cre recombinase is expressed in a T-cell specific manner. (J:194560, J:202955)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (species not specified) Summary of all recombinase alleles driven by Lck.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:194560 Lin MH, et al., B lymphocyte-induced maturation protein 1 (BLIMP-1) attenuates autoimmune diabetes in NOD mice by suppressing Th1 and Th17 cells. Diabetologia. 2013 Jan;56(1):136-46
• All: 3 reference(s)