Polr1cem1(IMPC)J
Endonuclease-mediated Allele Detail
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Symbol: |
Polr1cem1(IMPC)J |
Name: |
polymerase (RNA) I polypeptide C; endonuclease-mediated mutation 1, Jackson |
MGI ID: |
MGI:5901842 |
Gene: |
Polr1c Location: Chr17:46554846-46558971 bp, - strand Genetic Position: Chr17, 22.9 cM
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Alliance: |
Polr1cem1(IMPC)J page
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IMPC: |
Polr1c gene page |
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Strain of Origin: |
C57BL/6NJ
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Project Collection: |
IMPC
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Allele Type: |
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Endonuclease-mediated (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele from project Polr1c-8545J-8326M was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences TTGTACATCTGCCTTCGCCT, CCTACTGCTGGGGCTTTAGT, ACCACCCTACCTGCCCCAGA and GGTTCACACCTATGACAGTC, which resulted in a 535 bp deletion beginning at Chromosome 17 negative strand position 46,246,036 bp, CTGGGGCAGGTAGGGTGGTT, and ending after TCTTGTACATCTGCCTTCGC at 46,245,502 bp (GRCm38/mm10). This mutation deletes exon 4 and 402 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 83 and early truncation 7 amino acids later.
(J:188991)
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Inheritance: |
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Not Specified |
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012; |
All: |
3 reference(s) |
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