Zeb1^tm1.2Mpst
Targeted Allele Detail

Summary

• Symbol: Zeb1^tm1.2Mpst
• Name: zinc finger E-box binding homeobox 1; targeted mutation 1.2, Marc Stemmler
• MGI ID: MGI:5901940
• Synonyms: Zeb1^del
• Gene: Zeb1 Location: Chr18:5591860-5775467 bp, + strand Genetic Position: Chr18, 4.42 cM
• Alliance: Zeb1^tm1.2Mpst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239147
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette and left exon 6 floxed. Cre-mediated recombination removed exon 6. (J:239147)

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zeb1 Mutation: 65 strains or lines available

References

• Original: J:239147 Brabletz S, et al., Generation and characterization of mice for conditional inactivation of Zeb1. Genesis. 2017 Apr;55(4)
• All: 2 reference(s)