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Nt5dc2em1(IMPC)J
Endonuclease-mediated Allele Detail
Summary
Symbol: Nt5dc2em1(IMPC)J
Name: 5'-nucleotidase domain containing 2; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:5902345
Gene: Nt5dc2  Location: Chr14:30853046-30861081 bp, + strand  Genetic Position: Chr14, 19.09 cM
Alliance: Nt5dc2em1(IMPC)J page
IMPC: Nt5dc2 gene page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project Nt5dc2-8541J-1639M was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences TGGTCAGTGTCCTAGTTGAG, ATACTTAGTCAAGGGCCCCT, GGCTAGAGCCAACGGCACCA and GGTCGGCCCTGGACTGTGCA, which resulted in a 321 bp deletion beginning at Chromosome 14 positive strand position 31,136,450 bp, CAGGGGCCCTTGACTAAGTA, and ending after GGGGCTAGAGCCAACGGCAC at 31,136,770 bp (GRCm38/mm10). This mutation deletes exon 9 and 239 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 179 and early truncation 8 amino acids later. (J:188991)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nt5dc2 Mutation:  17 strains or lines available
References
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory