Foxf1^tm1.1Vvk
Targeted Allele Detail

Summary

• Symbol: Foxf1^tm1.1Vvk
• Name: forkhead box F1; targeted mutation 1.1, Vladimir V Kalinichenko
• MGI ID: MGI:5902536
• Synonyms: Foxf1^fl
• Gene: Foxf1 Location: Chr8:121811125-121814883 bp, + strand Genetic Position: Chr8, 70.31 cM, cytoband E1
• Alliance: Foxf1^tm1.1Vvk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 x 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the promotor region upstream of exon 1 and a second loxP site and a neomycin resistance gene cassette into intron 1. The neo cassette was deleted through subsequent flp-mediated recombination, leaving a conditional-ready allele with a floxed exon 1. (J:240455)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxf1 Mutation: 13 strains or lines available

References

• Original: J:240455 Ren X, et al., FOXF1 transcription factor is required for formation of embryonic vasculature by regulating VEGF signaling in endothelial cells. Circ Res. 2014 Sep 26;115(8):709-20
• All: 7 reference(s)