Pou4f3^{tm1.1(HBEGF)Rubel}
Targeted Allele Detail

Summary

• Symbol: Pou4f3^{tm1.1(HBEGF)Rubel}
• Name: POU domain, class 4, transcription factor 3; targeted mutation 1.1, Edwin Rubel
• MGI ID: MGI:5902780
• Synonyms: Pou4f3^DTR
• Gene: Pou4f3 Location: Chr18:42527662-42529158 bp, + strand Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
• Alliance: Pou4f3^{tm1.1(HBEGF)Rubel} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240454
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Pou4f3^{tm1.1(HBEGF)Rubel} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The human gene was inserted upstream of the translation start site and downstream of the promoter of the mouse host gene. The loxP site flanked neomycin resistance gene that was also inserted, was deleted through cre-mediated recombination. This leaves an allele with the Diphtheria Toxin sensitive human gene under control of the mouse promoter, rendering the cells where this allele is expressed sensitive to DT-induced cell death. (J:240454)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f3 Mutation: 25 strains or lines available

References

• Original: J:240454 Tong L, et al., Selective deletion of cochlear hair cells causes rapid age-dependent changes in spiral ganglion and cochlear nucleus neurons. J Neurosci. 2015 May 20;35(20):7878-91
• All: 2 reference(s)