Adamtsl4^tvrm267
Chemically induced Allele Detail

Summary

• Symbol: Adamtsl4^tvrm267
• Name: ADAMTS-like 4; translational vision research model 267
• MGI ID: MGI:5902816
• Gene: Adamtsl4 Location: Chr3:95583511-95595228 bp, - strand Genetic Position: Chr3, 40.74 cM
• Alliance: Adamtsl4^tvrm267 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: This ENU-induced C to T point substitution at c.1825 is predicted to replace glutamine at amino acid 609, which is near the C-terminal end of the spacer module, with a stop codon. (J:226844)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adamtsl4 Mutation: 76 strains or lines available

References

• Original: J:226844 Collin GB, et al., Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Hum Mol Genet. 2015 Dec 15;24(24):6958-74
• All: 1 reference(s)