Lrrtm1^{em1(cre/ERT2)Amc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrtm1^{em1(cre/ERT2)Amc}
• Name: leucine rich repeat transmembrane neuronal 1; endonuclease-mediated mutation 1, Andrew P McMahon
• MGI ID: MGI:5902946
• Synonyms: Lrrtm1-IRES-CRE-ERT2
• Gene: Lrrtm1 Location: Chr6:77219672-77234774 bp, + strand Genetic Position: Chr6, 33.89 cM
• Alliance: Lrrtm1^{em1(cre/ERT2)Amc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159099
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Lrrtm1^{em1(cre/ERT2)Amc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lrrtm1 (MGI:2389173)

• Mutation details: Plasmids encoding a signal guide RNA designed to introduce a cre/ERT2 knock-in mutation into 3' UTR near the stop codon of the Lrrtm1 gene and the cas9 nuclease were introduced into the cytoplasm of C57BL/6N-derived JM8.N4 ES cells. (J:159099)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lrrtm1 (mouse) Summary of all recombinase alleles driven by Lrrtm1. Alliance mouse Lrrtm1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrtm1 Mutation: 37 strains or lines available

References

• Original: J:159099 McMahon A, et al., Summary of mouse strains characterized by GUDMAP consortium. Unpublished. 2010
• All: 1 reference(s)