Atxn1l^tm2Hzo
Targeted Allele Detail

Summary

• Symbol: Atxn1l^tm2Hzo
• Name: ataxin 1-like; targeted mutation 2, Huda Y Zoghbi
• MGI ID: MGI:5903201
• Synonyms: Atxn1l^flox
• Gene: Atxn1l Location: Chr8:110453083-110464371 bp, - strand Genetic Position: Chr8, 57.22 cM
• Alliance: Atxn1l^tm2Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178303
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was introduced to intron 3 and a loxP-flanked TK-neomycin resistance cassette was placed in exon 4 following the open reading frame. (J:178303)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atxn1l Mutation: 24 strains or lines available

References

• Original: J:178303 Lee Y, et al., ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011 Oct 18;21(4):746-57
• All: 4 reference(s)