Mymx^em1Shcs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mymx^em1Shcs
• Name: myomixer, myoblast fusion factor; endonuclease-mediated mutation 1, Srihari C Sampath
• MGI ID: MGI:5903202
• Synonyms: Minion^delta
• Gene: Mymx Location: Chr17:45911897-45913028 bp, - strand Genetic Position: Chr17, 22.59 cM
• Alliance: Mymx^em1Shcs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology introduced a 135 bp deletion in the single coding exon. Western blot analysis confirmed the absence of protein expression in limb and tongue at E16.5 and P0. (J:241565)

Expression

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mymx Mutation: 28 strains or lines available

References

• Original: J:241565 Zhang Q, et al., The microprotein Minion controls cell fusion and muscle formation. Nat Commun. 2017 Jun 01;8:15664
• All: 2 reference(s)