App^tm1.1Wevn
Targeted Allele Detail

Summary

• Symbol: App^tm1.1Wevn
• Name: amyloid beta precursor protein; targeted mutation 1.1, William Van Nostrand
• MGI ID: MGI:5903308
• Synonyms: AbetaPP/KPI^R13I
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^tm1.1Wevn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241632
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector was designed to substitute an arginine for isoleucine at amino acid position 13 by introducing two point mutations into the arginine codon (CGC to ATC). A loxP-flanked Neomycin cassette also was included in the construct. The R13I mutation is located on a 10 kb long arm fragment 300 bp downstream of exon 7. Cre-mediated recombination removed the loxP-flanked neo. Expression of APP protein is not affected. (J:241632)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any App Mutation: 103 strains or lines available

References

• Original: J:241632 Xu F, et al., Mutation of the Kunitz-type proteinase inhibitor domain in the amyloid beta-protein precursor abolishes its anti-thrombotic properties in vivo. Thromb Res. 2017 Jul;155:58-64
• All: 1 reference(s)