Tg(TcraS106-1,TcrbS106-1)TS1SWAjca
Transgene Detail
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| Symbol: |
Tg(TcraS106-1,TcrbS106-1)TS1SWAjca |
| Name: |
transgene insertion TS1SW, Andrew J Caton |
| MGI ID: |
MGI:5903429 |
| Synonyms: |
TS1(SW) |
| Transgene: |
Tg(TcraS106-1,TcrbS106-1)TS1SWAjca Location: unknown
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| Alliance: |
Tg(TcraS106-1,TcrbS106-1)TS1SWAjca page
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| Strain of Origin: |
C57BL/6 x BALB/c
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: The transgenic construct expresses a T cell receptor raised against hemagglutinin (HA) from influenza virus A/SW/33(SW), which contains an analog of the S1 determinant that differs from S1 by 2 substitutions, R to K at residue 113 and E to T at residue 120, isolated from hybridoma S106-1. This receptor is encoded by TCR Valpha8.3 and Vbeta10, and has a much lower affinity for the original S1 determinant than does Tg(Tcra/Tcrb)1Vbo .
(J:133154)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:133154 Jordan MS, et al., Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol. 2001 Apr;2(4):301-6 |
| All: |
5 reference(s) |
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Analysis Tools
