Poln^tm1.2Rwd
Targeted Allele Detail

Summary

• Symbol: Poln^tm1.2Rwd
• Name: DNA polymerase N; targeted mutation 1.2, Richard D Wood
• MGI ID: MGI:5903477
• Synonyms: Poln^deltaEx2
• Gene: Poln Location: Chr5:34164523-34326792 bp, - strand Genetic Position: Chr5, 17.83 cM, cytoband C1
• Alliance: Poln^tm1.2Rwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241704
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. (J:241704)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Poln Mutation: 48 strains or lines available

References

• Original: J:241704 Takata KI, et al., Analysis of DNA polymerase nu function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet. 2017 Jun;13(6):e1006818
• All: 1 reference(s)