Mettl2^em1Nju
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mettl2^em1Nju
• Name: methyltransferase 2, methylcytidine; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:5903740
• Gene: Mettl2 Location: Chr11:105017251-105031220 bp, + strand Genetic Position: Chr11, 68.61 cM
• Alliance: Mettl2^em1Nju page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 targeted exon 3 and generated a 53 bp deletion. (J:241777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl2 Mutation: 40 strains or lines available

References

• Original: J:241777 Xu L, et al., Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. J Biol Chem. 2017;292(35):14695-14703
• All: 1 reference(s)