Mettl8em1Nju
Endonuclease-mediated Allele Detail
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| Symbol: |
Mettl8em1Nju |
| Name: |
methyltransferase 8, methylcytidine; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University |
| MGI ID: |
MGI:5903742 |
| Gene: |
Mettl8 Location: Chr2:70794905-70885927 bp, - strand Genetic Position: Chr2, 42.34 cM
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| Alliance: |
Mettl8em1Nju page
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Endonuclease-mediated (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: CRISPR/Cas9 targeted exon 4 and generated a 92 bp deletion. Western blot analysis confirmed the absence of protein expression in the liver and brain.
(J:241777)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mettl8 Mutation: |
47 strains or lines available
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| Original: |
J:241777 Xu L, et al., Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans. J Biol Chem. 2017;292(35):14695-14703 |
| All: |
1 reference(s) |
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Analysis Tools
