Lrfn2^tm1.1Jaru
Targeted Allele Detail

Summary

• Symbol: Lrfn2^tm1.1Jaru
• Name: leucine rich repeat and fibronectin type III domain containing 2; targeted mutation 1.1, Jun Aruga
• MGI ID: MGI:5904006
• Gene: Lrfn2 Location: Chr17:49239407-49404616 bp, + strand Genetic Position: Chr17, 24.66 cM, cytoband C
• Alliance: Lrfn2^tm1.1Jaru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241916
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, containing the ATG translation initiation codon, was replaced with a loxP-flanked neomycin resistance cassette. Cre-mediated recombination removed the neomycin cassette. Immunoblotting confirmed absence of protein in homozygotes. (J:241916)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrfn2 Mutation: 46 strains or lines available

References

• Original: J:241916 Morimura N, et al., Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice. Nat Commun. 2017 Jun 12;8:15800
• All: 2 reference(s)