Ttc9^tm1Vcl
Targeted Allele Detail

Summary

• Symbol: Ttc9^tm1Vcl
• Name: tetratricopeptide repeat domain 9; targeted mutation 1, Valerie Lin
• MGI ID: MGI:5904133
• Synonyms: Ttc9a^-
• Gene: Ttc9 Location: Chr12:81678023-81714331 bp, + strand Genetic Position: Chr12, 37.85 cM
• Alliance: Ttc9^tm1Vcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241703
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1, encoding 70% of the protein, was replaced by a loxP-flanked neomycin resistance cassette. Western blot and immunoblot analysis of brain, mammary gland, lung and uterus confirmed that no protein was expressed in mutant mice. (J:241703)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttc9 Mutation: 9 strains or lines available

References

• Original: J:241703 Shrestha S, et al., Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. Int J Biol Sci. 2015;11(4):434-47
• All: 2 reference(s)