Zscan21tm1.1Jiwa
Targeted Allele Detail
|
Symbol: |
Zscan21tm1.1Jiwa |
Name: |
zinc finger and SCAN domain containing 21; targeted mutation 1.1, Jiaxiang Wang |
MGI ID: |
MGI:5904160 |
Synonyms: |
Zfp38flox |
Gene: |
Zscan21 Location: Chr5:138115165-138132527 bp, + strand Genetic Position: Chr5, 76.96 cM
|
Alliance: |
Zscan21tm1.1Jiwa page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:237046
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Conditional ready, No functional change) |
Mutation: |
|
Insertion
|
|
|
Mutation details: Exon 4 was flanked by a loxP site and a loxP-flanked Neo cassette was inserted into intron 4. The neo cassette was removed via cre-mediated recombination leaving exon 4 floxed.
(J:237046)
|
|
|
Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
|
Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
---|
Loading... | | | involves: FVB/NJ | |
|
Phenotypes: |
Affected Systems |
|
|
cellular
|
√
|
abnormal spermatid morphology
|
√
|
abnormal spermatocyte morphology
|
√
|
abnormal X-Y chromosome synapsis during male meiosis
|
√
|
arrest of male meiosis
|
√
|
abnormal double-strand DNA break repair
|
√
|
endocrine/exocrine glands
|
√
|
decreased testis weight
|
√
|
homeostasis/metabolism
|
√
|
abnormal double-strand DNA break repair
|
√
|
reproductive system
|
√
|
abnormal spermatid morphology
|
√
|
abnormal spermatocyte morphology
|
√
|
abnormal X-Y chromosome synapsis during male meiosis
|
√
|
arrest of male meiosis
|
√
|
decreased testis weight
|
√
|
male infertility
|
√
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Zscan21 Mutation: |
44 strains or lines available
|
|
Original: |
J:237046 Yan Z, et al., Transcription factor ZFP38 is essential for meiosis prophase I in male mice. Reproduction. 2016 Nov;152(5):431-7 |
All: |
1 reference(s) |
|