Wnt10a^tm1.1Smr
Targeted Allele Detail

Summary

• Symbol: Wnt10a^tm1.1Smr
• Name: wingless-type MMTV integration site family, member 10A; targeted mutation 1.1, Sarah E Millar
• MGI ID: MGI:5904667
• Synonyms: Wnt10a^KO
• Gene: Wnt10a Location: Chr1:74831178-74843335 bp, + strand Genetic Position: Chr1, 38.54 cM
• Alliance: Wnt10a^tm1.1Smr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242196
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted flanking exons 3 and 4, which encode 20 of the 24 conserved, functionally required cysteine residues. Mice carrying this allele were crossed with CMV-Cre mice to delete the loxP-flanked region. (J:242196)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt10a Mutation: 19 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: WNT10A mutation

References

• Original: J:242196 Xu M, et al., WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 07;8:15397
• All: 1 reference(s)