Tldc2^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tldc2^em1(IMPC)J
• Name: TBC/LysM associated domain containing 2; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:5904784
• Gene: Tldc2 Location: Chr2:156928975-156938402 bp, + strand Genetic Position: Chr2, 77.99 cM
• Alliance: Tldc2^em1(IMPC)J page
• IMPC: Tldc2 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele from project Tldc2-8630J-5356M was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences TCTGTGGCAGAGGGCATAAG, CAGTGTTGTGTAGGGACTGG, GGCCCATGGCCCTTTCCCAA and GTGTGACGTGACTGGGAACG, which resulted in a 470 bp deletion beginning at Chromosome 2 positive strand position 157,095,100 bp, GATCTGTGGCAGAGGGCATA, and ending after GTGACGTGACTGGGAACGAG at 157,095,569 bp (GRCm38/mm10). This mutation deletes exon 5 and 396 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 143 and early truncation 24 amino acids later. (J:188991)
• Inheritance: Not Specified

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tldc2 Mutation: 6 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)