Ampd1tm1c(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Ampd1tm1c(KOMP)Wtsi |
Name: |
adenosine monophosphate deaminase 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5905188 |
Synonyms: |
Ampd1tm1c |
Gene: |
Ampd1 Location: Chr3:102981330-103007036 bp, + strand Genetic Position: Chr3, 45.25 cM
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Alliance: |
Ampd1tm1c(KOMP)Wtsi page
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IMPC: |
Ampd1 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:240489
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 102985923 of Chromosome 3 upstream of exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 102986789. Exon is thus flanked by loxP sites. A "conditional ready" (floxed) allele was then created by flp recombinase expression in mice carrying this allele, which removes the lacZ and neo cassettes.
(J:204739, J:240489)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ampd1 Mutation: |
49 strains or lines available
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Original: |
J:240489 Pan Y, et al., Insertion of a knockout-first cassette in Ampd1 gene leads to neonatal death by disruption of neighboring genes expression. Sci Rep. 2016 Oct 24;6:35970 |
All: |
2 reference(s) |
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