Taco1^m1Anu
Chemically induced Allele Detail

Summary

• Symbol: Taco1^m1Anu
• Name: translational activator of mitochondrially encoded cytochrome c oxidase I; ENU mutation 1, Australian National University
• MGI ID: MGI:5905291
• Synonyms: Taco1^m1Apb, Taco1^mut
• Gene: Taco1 Location: Chr11:105956887-105964438 bp, + strand Genetic Position: Chr11, 68.89 cM, cytoband E1
• Alliance: Taco1^m1Anu page

Mutation origin

• Strain of Origin: C57BL/6NCrlAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU treatment caused a T491A substitution in exon 3, which changes isoleucine codon 164 into an asparagine codon (p.Ile164Asn). Ile164 is a conserved residue and in homozygous mice virtually no protein is detected in liver and heart mitochondria via immunoblotting. (J:239883)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taco1 Mutation: 22 strains or lines available

References

• Original: J:239883 Richman TR, et al., Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun. 2016 Jun 20;7:11884
• All: 2 reference(s)