Syde1^tm1.1Hwch
Targeted Allele Detail

Summary

• Symbol: Syde1^tm1.1Hwch
• Name: synapse defective 1, Rho GTPase, homolog 1 (C. elegans); targeted mutation 1.1, Hungwen Chen
• MGI ID: MGI:5905625
• Gene: Syde1 Location: Chr10:78420337-78427798 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Syde1^tm1.1Hwch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241798
• Parent Cell Line: C2J (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exons 2 through 4 and the selection cassette. (J:241798)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syde1 Mutation: 28 strains or lines available

References

• Original: J:241798 Lo HF, et al., Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion. J Pathol. 2017 Feb;241(3):324-336
• All: 1 reference(s)