Primpol^em1Nki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Primpol^em1Nki
• Name: primase and polymerase (DNA-directed); endonuclease-mediated mutation 1, The Netherlands Cancer Institute
• MGI ID: MGI:5905761
• Gene: Primpol Location: Chr8:47028629-47070247 bp, - strand Genetic Position: Chr8, 26.39 cM
• Alliance: Primpol^em1Nki page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• CRISPR/Cas9 technology deleted 4 bp (CCAA) in exon 5. (J:242620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Primpol Mutation: 48 strains or lines available

References

• Original: J:242620 Pilzecker B, et al., PrimPol prevents APOBEC/AID family mediated DNA mutagenesis. Nucleic Acids Res. 2016 Jun 02;44(10):4734-44
• All: 1 reference(s)