Tg(Myh6-Rest*)474Ysai
Transgene Detail

Summary

• Symbol: Tg(Myh6-Rest*)474Ysai
• Name: transgene insertion 474, Yoshihiko Saito
• MGI ID: MGI:5905765
• Synonyms: dnNRSF Tg
• Transgene: Tg(Myh6-Rest*)474Ysai Location: unknown
• Alliance: Tg(Myh6-Rest*)474Ysai page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Rest*)474Ysai expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	REST	dominant negative form

• Mutation details: A dominant-negative mutant neuron-restrictive silencer factor cDNA is under the control of the cardiac-specific alpha-MHC promoter. Two lines, 471 and 474, were generated. mRNA is expressed at a level 27-fold higher than endogenous mRNA in this line. Western blot confirmed that expression is restricted to the heart, though weak expression is seen in the lung. (J:86837)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:86837 Kuwahara K, et al., NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function. EMBO J. 2003 Dec 1;22(23):6310-21
• All: 7 reference(s)