Cuzd1^tm1Bag
Targeted Allele Detail

Summary

• Symbol: Cuzd1^tm1Bag
• Name: CUB and zona pellucida-like domains 1; targeted mutation 1, Milan Bagchi
• MGI ID: MGI:5906132
• Synonyms: Cuzd1-null
• Gene: Cuzd1 Location: Chr7:130910283-130924021 bp, - strand Genetic Position: Chr7, 73.81 cM
• Alliance: Cuzd1^tm1Bag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette has replaced exons 3-6, which encode the first and second CUB domains of the protein. Immunofluorescence analysis of mammary glands of homozygous mutant females at puberty (5 weeks), late pregnancy (day 18), and early lactation (postpartum day 2) detected no expression of the targeted gene at any developmental stage. (J:242064)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cuzd1 Mutation: 44 strains or lines available

References

• Original: J:242064 Mapes J, et al., CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet. 2017 Mar;13(3):e1006654
• All: 1 reference(s)