Nop53^tm2.1Asuz
Targeted Allele Detail

Summary

• Symbol: Nop53^tm2.1Asuz
• Name: NOP53 ribosome biogenesis factor; targeted mutation 2.1, Akira Suzuki
• MGI ID: MGI:5906164
• Synonyms: Pict1^flox
• Gene: Nop53 Location: Chr7:15671760-15680033 bp, - strand Genetic Position: Chr7, 8.64 cM, cytoband A2
• Alliance: Nop53^tm2.1Asuz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241062
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site flanked hygromycin resistance gene cassette was inserted into intron 2 and a third loxP site into intron 5. The hygro cassette was removed through cre-mediated recombination. This leaves a conditional-ready allele with exons 3-5 floxed. (J:241062)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nop53 Mutation: 28 strains or lines available

References

• Original: J:241062 Sasaki M, et al., Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011 Jul 31;17(8):944-51
• All: 1 reference(s)