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Tg(Myh6-ACTC1*E361G)361.20Sbm
Transgene Detail
Summary
Symbol: Tg(Myh6-ACTC1*E361G)361.20Sbm
Name: transgene insertion 361.20, Steven B Marston
MGI ID: MGI:5906238
Synonyms: ACTC E361G
Transgene: Tg(Myh6-ACTC1*E361G)361.20Sbm  Location: unknown  
Alliance: Tg(Myh6-ACTC1*E361G)361.20Sbm page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-ACTC1*E361G)361.20Sbm expresses 1 gene
 
Mutation detailsThe heart restricted murine alpha-myosin heavy chain promoter drives the expression of human cardiac actin with a glycine substitution for glutamic acid at amino acid 361 (E361G). This is a dominant negative mutation. Two lines were established: 361.20 and 361.13. Mice express this mutation at around 50% of total actin in the heart. (J:242344)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:242344 Song W, et al., Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol. 2010 Sep;49(3):380-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory