Hand2os1^em1Eno
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hand2os1^em1Eno
• Name: Hand2, opposite strand 1; endonuclease-mediated mutation 1, Eric N Olson
• MGI ID: MGI:5906350
• Gene: Hand2os1 Location: Chr8:57757296-57773894 bp, - strand Genetic Position: Chr8, Syntenic
• Alliance: Hand2os1^em1Eno page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: TALEN technology inserted a triple adenylation sequence into exon 2. QPCR confirmed the absence of transcript expression in E10.5 hearts. (J:241318)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2os1 Mutation: 0 strains or lines available

References

• Original: J:241318 Anderson KM, et al., Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development. Nature. 2016 Nov 17;539(7629):433-436
• All: 1 reference(s)