Dars1Gt(Ayu17-9366)Tgjp
Gene trapped Allele Detail
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Symbol: |
Dars1Gt(Ayu17-9366)Tgjp |
Name: |
aspartyl-tRNA synthetase 1; gene trap Ayu17-9366, TransGenic |
MGI ID: |
MGI:5906383 |
Synonyms: |
DarsGt(pU-17)9366Tgjp |
Gene: |
Dars1 Location: Chr1:128291444-128345105 bp, - strand Genetic Position: Chr1, 55.8 cM
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Alliance: |
Dars1Gt(Ayu17-9366)Tgjp page
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Allele Type: |
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Gene trapped (Null/knockout) |
Mutation: |
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Insertion of gene trap vector
Vector: pU-17
Vector Type: gene trap
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Mutation details: The gene trap vector pUC17, which contains an En splice acceptor, lox71 site, lacZ gene, neo cassette, loxP site and lox2272 site, was inserted into intron 4. The insertion results in truncation after the first 320 bp of endogenous sequence and resulting in the loss of the catalytic domain. QRT-PCR confirmed the transcriptnis virtually absent in E11 embryos.
(J:242754)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dars1 Mutation: |
69 strains or lines available
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Original: |
J:242754 Frohlich D, et al., In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL. Neurobiol Dis. 2017 Jan;97(Pt A):24-35 |
All: |
1 reference(s) |
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