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Dars1Gt(Ayu17-9366)Tgjp
Gene trapped Allele Detail
Summary
Symbol: Dars1Gt(Ayu17-9366)Tgjp
Name: aspartyl-tRNA synthetase 1; gene trap Ayu17-9366, TransGenic
MGI ID: MGI:5906383
Synonyms: DarsGt(pU-17)9366Tgjp
Gene: Dars1  Location: Chr1:128291444-128345105 bp, - strand  Genetic Position: Chr1, 55.8 cM
Alliance: Dars1Gt(Ayu17-9366)Tgjp page
Mutation
origin
Mutant Cell Line:  Ayu17-9366
Germline Transmission:  Earliest citation of germline transmission: J:242754
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Gene trapped (Null/knockout)
Mutation:    Insertion of gene trap vector     Vector: pU-17     Vector Type: gene trap
 
Mutation detailsThe gene trap vector pUC17, which contains an En splice acceptor, lox71 site, lacZ gene, neo cassette, loxP site and lox2272 site, was inserted into intron 4. The insertion results in truncation after the first 320 bp of endogenous sequence and resulting in the loss of the catalytic domain. QRT-PCR confirmed the transcriptnis virtually absent in E11 embryos. (J:242754)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dars1 Mutation:  69 strains or lines available
References
Original:  J:242754 Frohlich D, et al., In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL. Neurobiol Dis. 2017 Jan;97(Pt A):24-35
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory