Pnpla1^tm1Murm
Targeted Allele Detail

Summary

• Symbol: Pnpla1^tm1Murm
• Name: patatin-like phospholipase domain containing 1; targeted mutation 1, Makoto Murakami
• MGI ID: MGI:5906479
• Gene: Pnpla1 Location: Chr17:29077385-29109283 bp, + strand Genetic Position: Chr17, 15.03 cM
• Alliance: Pnpla1^tm1Murm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240682
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The KOMP vector HTGRS6008_A_AO4 inserted an FRT site, IRES-lacZ reporter gene, FRT site and loxP site upstream of exon 2. An additional loxP site was inserted downstream of exon 3. (J:240682)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pnpla1 Mutation: 28 strains or lines available

References

• Original: J:240682 Hirabayashi T, et al., PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. Nat Commun. 2017 Mar 01;8:14609
• All: 1 reference(s)