Cdk12^tm1.2Mjfn
Targeted Allele Detail

Summary

• Symbol: Cdk12^tm1.2Mjfn
• Name: cyclin dependent kinase 12; targeted mutation 1.2, Ming-Ji Fann
• MGI ID: MGI:5906608
• Gene: Cdk12 Location: Chr11:98093885-98169330 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Cdk12^tm1.2Mjfn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242195
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were floxed and an FRT flanked neo cassette was inserted via homologous recombination. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 3 and 4. The predicted product lacks the kinase domain. (J:242195)

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk12 Mutation: 75 strains or lines available

References

• Original: J:242195 Juan HC, et al., Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ. 2016 Jun;23(6):1038-48
• All: 1 reference(s)