Tg(Myh6-Rxra)41Pcn
Transgene Detail

Summary

• Symbol: Tg(Myh6-Rxra)41Pcn
• Name: transgene insertion 41, Pierre Chambon
• MGI ID: MGI:5906918
• Transgene: Tg(Myh6-Rxra)41Pcn Location: unknown
• Alliance: Tg(Myh6-Rxra)41Pcn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Rxra)41Pcn expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rxra (MGI:98214)

• Mutation details: 5.5 kb of the myosin heavy chain alpha gene, including the promoter and the first 3 untranslated exons, drive the heart-specific expression of mouse Rxra cDNA linked to a 1.3-kb fragment from the human progesterone receptor 3' UTR region to be used as a tag. Two lines were generated: 41 and 54.This line has a copy number of 16 and is the high expressing line. (J:60351)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:60351 Subbarayan V, et al., RXRalpha overexpression in cardiomyocytes causes dilated cardiomyopathy but fails to rescue myocardial hypoplasia in RXRalpha-null fetuses. J Clin Invest. 2000 Feb;105(3):387-94
• All: 1 reference(s)