Zdhhc16^tm1Goff
Targeted Allele Detail

Summary

• Symbol: Zdhhc16^tm1Goff
• Name: zinc finger, DHHC domain containing 16; targeted mutation 1, Stephen P Goff
• MGI ID: MGI:5907020
• Gene: Zdhhc16 Location: Chr19:41921919-41932543 bp, + strand Genetic Position: Chr19, 35.48 cM, cytoband D1
• Alliance: Zdhhc16^tm1Goff page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228307
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis of liver RNA from homozygous pups confirmed the absence of mRNA expression. (J:228307)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zdhhc16 Mutation: 25 strains or lines available

References

• Original: J:228307 Zhou T, et al., Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71
• All: 2 reference(s)