Srebf2^tm1Jdh
Targeted Allele Detail

Summary

• Symbol: Srebf2^tm1Jdh
• Name: sterol regulatory element binding factor 2; targeted mutation 1, Jay D Horton
• MGI ID: MGI:5907035
• Synonyms: Srebf-2^flox
• Gene: Srebf2 Location: Chr15:82031455-82089580 bp, + strand Genetic Position: Chr15, 38.49 cM
• Alliance: Srebf2^tm1Jdh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241873
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector contains a loxP site inserted into the promoter region 660 bp upstream of exon 1 and a loxP site followed by a FRT-flanked neomycin cassette inserted into intron 1. (J:241873)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Srebf2 Mutation: 78 strains or lines available

References

• Original: J:241873 Rong S, et al., Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice. Elife. 2017 Feb 28;6:e25015
• All: 2 reference(s)