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Vps13ctm1.1Geno
Targeted Allele Detail
Summary
Symbol: Vps13ctm1.1Geno
Name: vacuolar protein sorting 13C; targeted mutation 1.1, Genoway
MGI ID: MGI:5907128
Synonyms: Vps13cfl
Gene: Vps13c  Location: Chr9:67747678-67902920 bp, + strand  Genetic Position: Chr9, 36.77 cM
Alliance: Vps13ctm1.1Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:241413
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted upstream of exon 1 and in intron 1. This creates a conditional-ready allele with exon 1 floxed. Exon 1 contains the translation start site and its deletion would create a null allele. An FRT site flanked neomycin resistance gene cassette that was inserted into intron 1 was removed through flp-mediated recombination. (J:241413)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vps13c Mutation:  169 strains or lines available
References
Original:  J:241413 Mehta ZB, et al., Changes in the expression of the type 2 diabetes-associated gene VPS13C in the beta-cell are associated with glucose intolerance in humans and mice. Am J Physiol Endocrinol Metab. 2016 Aug 01;311(2):E488-507
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory