Vps13ctm1.1Geno
Targeted Allele Detail
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Symbol: |
Vps13ctm1.1Geno |
Name: |
vacuolar protein sorting 13C; targeted mutation 1.1, Genoway |
MGI ID: |
MGI:5907128 |
Synonyms: |
Vps13cfl |
Gene: |
Vps13c Location: Chr9:67747678-67902920 bp, + strand Genetic Position: Chr9, 36.77 cM
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Alliance: |
Vps13ctm1.1Geno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:241413
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: LoxP sites were inserted upstream of exon 1 and in intron 1. This creates a conditional-ready allele with exon 1 floxed. Exon 1 contains the translation start site and its deletion would create a null allele. An FRT site flanked neomycin resistance gene cassette that was inserted into intron 1 was removed through flp-mediated recombination.
(J:241413)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Vps13c Mutation: |
169 strains or lines available
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Original: |
J:241413 Mehta ZB, et al., Changes in the expression of the type 2 diabetes-associated gene VPS13C in the beta-cell are associated with glucose intolerance in humans and mice. Am J Physiol Endocrinol Metab. 2016 Aug 01;311(2):E488-507 |
All: |
1 reference(s) |
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