Rnf170^{Gt(OST104375)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rnf170^{Gt(OST104375)Lex}
• Name: ring finger protein 170; gene trap OST104375, Lexicon Genetics
• MGI ID: MGI:5907138
• Gene: Rnf170 Location: Chr8:26609396-26633903 bp, + strand Genetic Position: Chr8, 14.38 cM, cytoband A3
• Alliance: Rnf170^{Gt(OST104375)Lex} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:226836
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The VICTR48 gene trap vector inserted in intron 2. RT-PCR analysis of brain, spinal cord, liver and brown adipose tissue from homozygous mice confirmed the absence of mRNA expression. (J:226836)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnf170 Mutation: 16 strains or lines available

References

• Original: J:226836 Kim Y, et al., Age-dependent gait abnormalities in mice lacking the Rnf170 gene linked to human autosomal-dominant sensory ataxia. Hum Mol Genet. 2015 Dec 20;24(25):7196-206
• All: 1 reference(s)