Mirc6^tm1.1Mzhu
Targeted Allele Detail

Summary

• Symbol: Mirc6^tm1.1Mzhu
• Name: microRNA cluster 6, including Mir379 through Mir544; targeted mutation 1.1, Min-Sheng Zhu
• MGI ID: MGI:5907298
• Synonyms: miR-379cl^-
• Gene: Mirc6 Location: Chr12:109675494-109695836 bp Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227271
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mirc6^tm1.1Mzhu involves 24 genes/genome features (Mir379, Mir411, Mir299a ...) View all
• Mutation details: A loxP site was inserted upstream of Mir379, an FRT and LoxP site were inserted downstream of Mir667 and an FRT flanked neo cassette and loxP site were inserted downstream of Mir544 via homologous recombination. Recombinase mediated recombination removed the entire cluster and the neo cassette. (J:227271)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc6 Mutation: 3 strains or lines available

References

• Original: J:227271 Gao YQ, et al., Regulation of DLK1 by the maternally expressed miR-379/miR-544 cluster may underlie callipyge polar overdominance inheritance. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13627-32
• All: 1 reference(s)