Mlip^{tm1.1(cre)Dzw}
Targeted Allele Detail

Summary

• Symbol: Mlip^{tm1.1(cre)Dzw}
• Name: muscular LMNA-interacting protein; targeted mutation 1.1, Da-Zhi Wang
• MGI ID: MGI:5907348
• Gene: Mlip Location: Chr9:77009366-77260062 bp, - strand Genetic Position: Chr9, 42.67 cM, cytoband E1
• Alliance: Mlip^{tm1.1(cre)Dzw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227485
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mlip^{tm1.1(cre)Dzw} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mlip (MGI:1916892)

• Mutation details: The ATG initiation site was replaced with a GFP-cre cassette and FRT flanked neo cassette via homologous recombination. Flp mediated recombination removed the neo cassette. QRT-PCR and Western blot analysis confirmed the absence of transcript and protein expression in hearts from homozygous mice. (J:227485)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mlip (mouse) Summary of all recombinase alleles driven by Mlip. Alliance mouse Mlip gene page

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlip Mutation: 28 strains or lines available

References

• Original: J:227485 Huang ZP, et al., Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 2;125(11):4122-34
• All: 1 reference(s)