Tg(Myh6-LPL*)357Ijg
Transgene Detail

Summary

• Symbol: Tg(Myh6-LPL*)357Ijg
• Name: transgene insertion 357, Ira J Goldberg
• MGI ID: MGI:5907463
• Transgene: Tg(Myh6-LPL*)357Ijg Location: unknown
• Alliance: Tg(Myh6-LPL*)357Ijg page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-LPL*)357Ijg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LPL (4023)

  Lpl	(MGI:96820)

• Mutation details: The human gene ligated to a glycosylphosphatidylinositol (GPI) anchor is under the control of the alpha myosin heavy chain promoter. The GPI anchors the LPL to the cardiomyocyte surface. Northern blot analysis confirmed high expression of the transgene only in the heart. Hearts, but not post-heparin plasma, contains human lipoprotein lipase activity. Three lines were generated; 346, 357, and 358. (J:134550)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:134550 Yagyu H, et al., Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest. 2003 Feb;111(3):419-26
• All: 1 reference(s)