Mcm3^tm1.2Geno
Targeted Allele Detail

Summary

• Symbol: Mcm3^tm1.2Geno
• Name: minichromosome maintenance complex component 3; targeted mutation 1.2, Genoway
• MGI ID: MGI:5907492
• Synonyms: Mcm3^-
• Gene: Mcm3 Location: Chr1:20873192-20890536 bp, - strand Genetic Position: Chr1, 6.5 cM, cytoband A3-A5
• Alliance: Mcm3^tm1.2Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227638
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted in intron 13 and IRES-EGFP-Luciferase cassette, FRT flanked neo cassette and loxP site were inserted after the stop codon in exon 17. Recombinase mediated recombination removed exons 14-17 and the reporter and neo cassettes. (J:227638)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mcm3 Mutation: 43 strains or lines available

References

• Original: J:227638 Alvarez S, et al., Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality. Nat Commun. 2015;6:8548
• All: 1 reference(s)